There are many different clients that a user can utilize to access information in an Exchange 2016 mailbox. These clients include desktop programs such as Outlook 2016, Outlook on the web, and mobile clients such as mobile phones, tablets, and other mobile devices.
Supported Clients
Exchange 2016 mailbox are supported from the clients below:
Outlook 2016
Outlook 2013
Outlook 2010 SP2 and updates KB2956191 and KB2965295
Outlook for Mac for Office 365
Outlook for Mac 2016
Mobile Devices
Most mobile phones or tablets are capable of using Autodiscover in Exchange to configure the mobile email client to use Exchange ActiveSync
Outlook on the Web
The user interface in Outlook on the web (formerly known as Outlook Web App) for Exchange Server 2016 has been optimized and simplified for use with phones and tablets. Most of the web browsers give users access to more Outlook features.
Conclusion
Exchange 2016 mailboxes can be browsed via any supported edition of Outlook, via mobile devices and of course on the go via any browser.